Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients

BACKGROUND: In preclinical murine and early clinical studies of hematopoietic cell transplantation, engineering of donor grafts with defined ratios of CD4(+)CD25(+)FoxP3(+) Tregs to conventional T cells (Tcons) results in the prevention of graft-versus-host disease and improved immune reconstitution...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Meyer, Everett H., Laport, Ginna, Xie, Bryan J., MacDonald, Kate, Heydari, Kartoosh, Sahaf, Bita, Tang, Sai-Wen, Baker, Jeanette, Armstrong, Randall, Tate, Keri, Tadisco, Cynthia, Arai, Sally, Johnston, Laura, Lowsky, Robert, Muffly, Lori, Rezvani, Andrew R., Shizuru, Judith, Weng, Wen-Kai, Sheehan, Kevin, Miklos, David, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542607/
https://ncbi.nlm.nih.gov/pubmed/31092732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127244
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