Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation

Biomechanical forces and endothelial-mesenchymal transition (EndoMT) are known to mediate valvulogenesis. However, the relative contributions of myocardial contractile and hemodynamic shear forces remain poorly understood. We integrated 4D light-sheet imaging of transgenic zebrafish models with movi...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Hsu, Jeffrey J., Vedula, Vijay, Baek, Kyung In, Chen, Cynthia, Chen, Junjie, Chou, Man In, Lam, Jeffrey, Subhedar, Shivani, Wang, Jennifer, Ding, Yichen, Chang, Chih-Chiang, Lee, Juhyun, Demer, Linda L., Tintut, Yin, Marsden, Alison L., Hsiai, Tzung K.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542601/
https://ncbi.nlm.nih.gov/pubmed/30973827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124460
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