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Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines

Lantibiotics are a class of peptide antibiotics with activity against most Gram-positive bacteria. Lanthionine (Lan) and β-MeLan are unusual thioether-bridged, non-proteinogenic amino acids, which are characteristic features of lantibiotics. In this paper, we report the facile stereoselective synthe...

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Pubblicato in:Org Lett
Autori principali: Li, Ziran, Gentry, Zachary, Murphy, Brennan, VanNieuwenhze, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542561/
https://ncbi.nlm.nih.gov/pubmed/30855974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b00125
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