Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

Although by age forty, individuals with Down syndrome (DS) develop amyloid-β (Aβ) plaques and tau-containing neurofibrillary tangles (NFTs) linked to cognitive impairment in Alzheimer’s disease (AD), not all people with DS develop dementia. Whether Aβ plaques and NFTs are associated with individuals...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Principais autores: Perez, Sylvia E., Miguel, Jennifer C., He, Bin, Malek-Ahmadi, Michael, Abrahamson, Eric E., Ikonomovic, Milos D., Lott, Ira, Doran, Eric, Alldred, Melissa J., Ginsberg, Stephen D., Mufson, Elliott J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541490/
https://ncbi.nlm.nih.gov/pubmed/30734106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01965-6
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