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Critical role for Piccolo in synaptic vesicle retrieval

Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal loss. Our analysi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ackermann, Frauke, Schink, Kay Oliver, Bruns, Christine, Izsvák, Zsuzsanna, Hamra, F Kent, Rosenmund, Christian, Garner, Craig Curtis
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541439/
https://ncbi.nlm.nih.gov/pubmed/31074746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46629
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