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Reversible and Tunable Photoswitching of Protein Function through Genetic Encoding of Azobenzene Amino Acids in Mammalian Cells

The genetic encoding of three different azobenzene phenylalanines with different photochemical properties was achieved in human cells using an engineered pyrrolysyl tRNA/tRNA synthetase pair. In order to demonstrate reversible light-control of protein function, azobenzenes were site-specifically int...

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Publicat a:Chembiochem
Autors principals: Luo, Ji, Samanta, Subhas, Convertino, Marino, Dokholyan, Nikolay V., Deiters, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540996/
https://ncbi.nlm.nih.gov/pubmed/30277634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800226
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