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Reversible and Tunable Photoswitching of Protein Function through Genetic Encoding of Azobenzene Amino Acids in Mammalian Cells

The genetic encoding of three different azobenzene phenylalanines with different photochemical properties was achieved in human cells using an engineered pyrrolysyl tRNA/tRNA synthetase pair. In order to demonstrate reversible light-control of protein function, azobenzenes were site-specifically int...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Luo, Ji, Samanta, Subhas, Convertino, Marino, Dokholyan, Nikolay V., Deiters, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540996/
https://ncbi.nlm.nih.gov/pubmed/30277634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800226
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