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Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids: exploring their in silico ADMET, ergosterol inhibition and ROS inducing potential

A series of new 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids (5a–u) were designed, synthesized and evaluated for their antimicrobial activity. Compounds 5d, 5g, 5j, 5k and 5q demonstrated significant activity against the entire panel of test pathogens. Further, compounds 5d and 5...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Shareef, Mohd Adil, Sirisha, K., Khan, Irfan, Sayeed, Ibrahim Bin, Jadav, Surender Singh, Ramu, Gopathi, Kumar, C. Ganesh, Kamal, Ahmed, Babu, Bathini Nagendra
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6540956/
https://ncbi.nlm.nih.gov/pubmed/31191871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00155g
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