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A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
Reactions that form sec–sec ethers are well known, but few lead to compounds with dense functionality around the O-linkage. Replacement of the α-glucopyranosyl unit of adenophostin A, a potent d-myo-inositol 1,4,5-trisphosphate (IP(3)R) agonist, with a d-chiro-inositol surrogate acting substantially...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6540904/ https://ncbi.nlm.nih.gov/pubmed/31171961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00445a |
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