In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome

Buprenorphine is the preferred treatment of opioid use disorder during pregnancy but can cause fetal opioid dependence and neonatal opioid withdrawal syndrome (NOWS). Notably, withdrawal severity is independent of maternal buprenorphine dose, suggesting that interindividual variance in pharmacokinet...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Griffin, Bryce A., Caperton, Caitlin O., Russell, Lauren N., Cabanlong, Christian V., Wilson, Catheryn D., Urquhart, Kyle R., Martins, Bradford S., Zita, Marcelle Dina, Patton, Amy L., Alund, Alexander W., Owens, S. Michael, Fantegrossi, William E., Moran, Jeffery H., Brents, Lisa K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538887/
https://ncbi.nlm.nih.gov/pubmed/31028107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254219
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