In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome

Buprenorphine is the preferred treatment of opioid use disorder during pregnancy but can cause fetal opioid dependence and neonatal opioid withdrawal syndrome (NOWS). Notably, withdrawal severity is independent of maternal buprenorphine dose, suggesting that interindividual variance in pharmacokinet...

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Detaylı Bibliyografya
Yayımlandı:J Pharmacol Exp Ther
Asıl Yazarlar: Griffin, Bryce A., Caperton, Caitlin O., Russell, Lauren N., Cabanlong, Christian V., Wilson, Catheryn D., Urquhart, Kyle R., Martins, Bradford S., Zita, Marcelle Dina, Patton, Amy L., Alund, Alexander W., Owens, S. Michael, Fantegrossi, William E., Moran, Jeffery H., Brents, Lisa K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2019
Konular:
Behavioral Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538887/
https://ncbi.nlm.nih.gov/pubmed/31028107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254219
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