Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia

Gilteritinib induces 2 distinct marrow responses in FLT3-mutated AML: responses with and without differentiation. Ongoing clonal hematopoiesis is ubiquitous during gilteritinib therapy and may promote genetic evolution and drug resistance.

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Bibliographic Details
Published in:Blood Adv
Main Authors: McMahon, Christine M., Canaani, Jonathan, Rea, Bryan, Sargent, Rachel L., Qualtieri, Julianne N., Watt, Christopher D., Morrissette, Jennifer J. D., Carroll, Martin, Perl, Alexander E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Stimulus Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538870/
https://ncbi.nlm.nih.gov/pubmed/31122910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018029496
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