Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT(3) Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

Cannabidiol (CBD) is a nonpsychotropic constituent of Cannabis sativa L. It is suggested to be useful in hypertension. Under in vitro conditions, it activates vanilloid TRPV1 and inhibits serotonin 5-HT(3) receptors, i.e., receptors involved in the Bezold-Jarisch reflex stimulation. The aim of our s...

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Vydáno v:Front Pharmacol
Hlavní autoři: Kossakowski, Rafał, Schlicker, Eberhard, Toczek, Marek, Weresa, Jolanta, Malinowska, Barbara
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538767/
https://ncbi.nlm.nih.gov/pubmed/31178718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00500
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