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Delineating the role of eIF2α in retinal degeneration

Activation of the unfolded protein response has been detected in various animal models of retinal degeneration. The PERK branch converges on eIF2α to regulate protein synthesis. We previously reported that diseased retinas produce less protein as they degenerate. We also proposed that the majority o...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Starr, Christopher R., Gorbatyuk, Marina S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538684/
https://ncbi.nlm.nih.gov/pubmed/31138784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1641-y
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