Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?

Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid (FA) and cholesterol metabolism play important roles in ccRCC development. As a nuclear transcription factor receptor, Liver X receptor (LXR) regulates a variety of key mole...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Wu, Guangzhen, Wang, Qinglian, Xu, Yingkun, Li, Jianyi, Zhang, Hongge, Qi, Guanghui, Xia, Qinghua
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538631/
https://ncbi.nlm.nih.gov/pubmed/31138790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1654-6
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