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Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition
Inhibition of type 1 IGF receptor (IGF-1R) sensitizes to DNA-damaging cancer treatments, and delays repair of DNA double strand breaks (DSBs) by non-homologous end-joining and homologous recombination (HR). In a recent screen for mediators of resistance to IGF-1R inhibitor AZ12253801, we identified...
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| Pubblicato in: | Int J Cancer |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6538529/ https://ncbi.nlm.nih.gov/pubmed/25388513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29327 |
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