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Identification of epitopes in ovalbumin that provide insights for cancer neoepitopes

MHC I–restricted epitopes of chicken ovalbumin (OVA) were originally identified using CD8(+) T cells as probes. Here, using bioinformatics tools, we identify 4 additional epitopes in OVA in addition to a cryptic epitope. Each additional epitope is presented in vivo, as deduced from the lack of CD8(+...

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Publicat a:JCI Insight
Autors principals: Karandikar, Sukrut Hemant, Sidney, John, Sette, Alessandro, Selby, Mark Joseph, Korman, Alan Jerry, Srivastava, Pramod Kumar
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538383/
https://ncbi.nlm.nih.gov/pubmed/30869653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127882
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