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Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset

BACKGROUND: Correcting a heterogeneous dataset that presents artefacts from several confounders is often an essential bioinformatics task. Attempting to remove these batch effects will result in some biologically meaningful signals being lost. Thus, a central challenge is assessing if the removal of...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Somekh, Judith, Shen-Orr, Shai S, Kohane, Isaac S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537327/
https://ncbi.nlm.nih.gov/pubmed/31138121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2855-9
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