Constrained instruments and their application to Mendelian randomization with pleiotropy

In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions, one of which is that the genetic vari...

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Detaylı Bibliyografya
Yayımlandı:Genet Epidemiol
Asıl Yazarlar: Jiang, Lai, Oualkacha, Karim, Didelez, Vanessa, Ciampi, Antonio, Rosa‐Neto, Pedro, Benedet, Andrea L., Mathotaarachchi, Sulantha, Richards, John Brent, Greenwood, Celia M. T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537099/
https://ncbi.nlm.nih.gov/pubmed/30635941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22184
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