Constrained instruments and their application to Mendelian randomization with pleiotropy

In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions, one of which is that the genetic vari...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genet Epidemiol
Prif Awduron: Jiang, Lai, Oualkacha, Karim, Didelez, Vanessa, Ciampi, Antonio, Rosa‐Neto, Pedro, Benedet, Andrea L., Mathotaarachchi, Sulantha, Richards, John Brent, Greenwood, Celia M. T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537099/
https://ncbi.nlm.nih.gov/pubmed/30635941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22184
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