Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

The astrocyte-specific enzyme glutamine synthetase (GS), which catalyzes the amidation of glutamate to glutamine, plays an essential role in supporting neurotransmission and in limiting NH(4)(+) toxicity. Accordingly, deficits in GS activity contribute to epilepsy and neurodegeneration. Despite its...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Huyghe, Deborah, Denninger, Andrew R., Voss, Caroline M., Frank, Pernille, Gao, Ning, Brandon, Nicholas, Waagepetersen, Helle S., Ferguson, Andrew D., Pangalos, Menelas, Doig, Peter, Moss, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536897/
https://ncbi.nlm.nih.gov/pubmed/31178690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00120
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