O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells. TxNIP is a scaffold protein interacting with target proteins to inhibit or stimulate their activity. Recent studies reported that high glucose stimul...

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Bibliographische Detailangaben
Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Filhoulaud, Gaelle, Benhamed, Fadila, Pagesy, Patrick, Bonner, Caroline, Fardini, Yann, Ilias, Anissa, Movassat, Jamileh, Burnol, Anne-Françoise, Guilmeau, Sandra, Kerr-Conte, Julie, Pattou, François, Issad, Tarik, Postic, Catherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536593/
https://ncbi.nlm.nih.gov/pubmed/31164864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00291
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