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Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines
Parthenolide (PT) is a sesquiterpene lactone isolated from Tanacetum parthenium. In this study, PT showed varying cytotoxic effects against different solid tumor cell lines. HCT116 (p53(+/+)) colon carcinoma cells and their parental HCT116 knockout p53 (p53(-/-)) cell lines showed a resistance degre...
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| Publicado no: | Front Pharmacol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6536578/ https://ncbi.nlm.nih.gov/pubmed/31164821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00542 |
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