Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy

Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated protein kinase (AMPK) that blocks mitochondrial complex I. The NLRP3 inflammasome has been demonstrated to be activated in dia...

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Detalles Bibliográficos
Publicado en:Int J Biol Sci
Autores principales: Yang, Fan, Qin, Ying, Wang, Yueqiu, Meng, Songyan, Xian, Huimin, Che, Hui, Lv, Jie, Li, Yang, Yu, Yahan, Bai, Yunlong, Wang, Lihong
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535781/
https://ncbi.nlm.nih.gov/pubmed/31182921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.29680
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