Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/Efficacy Biomarkers

BACKGROUND AND AIMS: To define pharmacodynamic and efficacy biomarkers in ulcerative colitis [UC] patients treated with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody, in the TURANDOT study. METHODS: Transcriptome, proteome and immunohistochemist...

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Veröffentlicht in:J Crohns Colitis
Hauptverfasser: Zhou, Huanyu, Xi, Li, Ziemek, Daniel, O’Neil, Shawn, Lee, Julie, Stewart, Zachary, Zhan, Yutian, Zhao, Shanrong, Zhang, Ying, Page, Karen, Huang, Austin, Maciejewski, Mateusz, Zhang, Baohong, Gorelick, Kenneth J, Fitz, Lori, Pradhan, Vivek, Cataldi, Fabio, Vincent, Michael, Von Schack, David, Hung, Kenneth, Hassan-Zahraee, Mina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535501/
https://ncbi.nlm.nih.gov/pubmed/30901380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjy217
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