Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin A. The classical mutation in HGPS leads to the production of a toxic truncated version of lamin A, progerin, which retains a fa...

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Detalles Bibliográficos
Publicado en:Biogerontology
Main Authors: Clements, Craig S., Bikkul, Mehmet U., Ofosu, Wendy, Eskiw, Christopher, Tree, David, Makarov, Evgeny, Kill, Ian R., Bridger, Joanna M.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535420/
https://ncbi.nlm.nih.gov/pubmed/31041622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-019-09807-4
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