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Development of a High Throughput Lysyl Hydroxylase (LH) Assay and Identification of Small Molecule Inhibitors Against LH2

Lysyl hydroxylase-2 (LH2) catalyzes the hydroxylation of telopeptidyl lysine residues on collagen, leading to the formation of stable collagen cross-links that connect collagen molecules and stabilize the extracellular matrix. High levels of LH2 have been reported in the formation and stabilization...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Devkota, Ashwini K., Veloria, John R., Guo, Hou-Fu, Kurie, Jonathan M., Cho, Eun Jeong, Dalby, Kevin N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535306/
https://ncbi.nlm.nih.gov/pubmed/30589612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218817057
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