Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

Lysyl hydroxylases catalyze hydroxylation of collagen lysines, and sustain essential roles in extracellular matrix (ECM) maturation and remodeling. Malfunctions in these enzymes cause severe connective tissue disorders. Human lysyl hydroxylase 3 (LH3/PLOD3) bears multiple enzymatic activities, as it...

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Publicat a:Nat Commun
Autors principals: Scietti, Luigi, Chiapparino, Antonella, De Giorgi, Francesca, Fumagalli, Marco, Khoriauli, Lela, Nergadze, Solomon, Basu, Shibom, Olieric, Vincent, Cucca, Lucia, Banushi, Blerida, Profumo, Antonella, Giulotto, Elena, Gissen, Paul, Forneris, Federico
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082870/
https://ncbi.nlm.nih.gov/pubmed/30089812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05631-5
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