Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

BACKGROUND: Microglia-mediated neuroinflammation is important in Alzheimer’s disease (AD) pathogenesis. Extracellular deposition of β-amyloid (Aβ), a major pathological hallmark of AD, can induce microglia activation. Adiponectin (APN), an adipocyte-derived adipokine, exerts anti-inflammatory effect...

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書目詳細資料
發表在:J Neuroinflammation
Main Authors: Jian, Min, Kwan, Jason Shing-Cheong, Bunting, Myriam, Ng, Roy Chun-Laam, Chan, Koon Ho
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
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Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535190/
https://ncbi.nlm.nih.gov/pubmed/31128596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1492-6
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