Protracted p53-independent stimulation of p21(WAF1/Cip1) fuels genomic instability by deregulating the replication licensing machinery

The cyclin-dependent kinase inhibitor p21(WAF1/Cip1) is the prototype downstream effector of the tumor suppressor protein p53. Yet, evidence from human cancer and mice models, imply that p21(WAF1/Cip1), under certain conditions, can exercise oncogenic activity. The mechanism behind this behavior is...

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Pubblicato in:Nat Cell Biol
Autori principali: Galanos, Panagiotis, Vougas, Konstantinos, Walter, David, Polyzos, Alexander, Maya-Mendoza, Apolinar, Haagensen, Emma J., Kokkalis, Antonis, Roumelioti, Fani-Marlen, Gagos, Sarantis, Tzetis, Maria, Canovas, Begoña, Igea, Ana, Kanavakis, Emanuel, Kletsas, Dimitris, Roninson, Igor, Garbis, Spiros D., Nebreda, Angel, Thanos, Dimitris, Townsend, Paul, Blow, J. Julian, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535144/
https://ncbi.nlm.nih.gov/pubmed/27323328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3378
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