Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis

Store-operated Ca(2+) entry (SOCE), mediated by the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) and the plasma membrane (PM) channel Orai1, is inhibited during mitosis. STIM1 phosphorylation has been suggested to mediate this inhibition, but it is unclear whether...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yu, Fang, Hubrack, Satanay Z., Chakraborty, Sumita, Sun, Lu, Alcantara-Adap, Ethel, Kulkarni, Rashmi, Billing, Anja M., Graumann, Johannes, Taylor, Colin W., Machaca, Khaled
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535005/
https://ncbi.nlm.nih.gov/pubmed/31064875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821399116
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