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Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

BACKGROUND: Chagas disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Current therapeutic management is limited to treatment with nitroheterocyclic drugs, such as nifurtimox (NFX) and benznidazole (BZ). Thus, the identification of affordable and rea...

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Detalhes bibliográficos
Publicado no:Parasit Vectors
Main Authors: Téllez, Jair, Romero, Ibeth, Romanha, Alvaro José, Steindel, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534881/
https://ncbi.nlm.nih.gov/pubmed/31126349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13071-019-3485-9
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