MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes

Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling t...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Lang, Yue, Zhao, Yue, Zheng, Chunxia, Lu, Yinghui, Wu, Junnan, Zhu, Xiaodong, Zhang, Mingchao, Yang, Fan, Xu, Xiaodong, Shi, Shaolin, Liu, Zhihong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534572/
https://ncbi.nlm.nih.gov/pubmed/31127093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1625-y
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