MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes

Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling t...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Lang, Yue, Zhao, Yue, Zheng, Chunxia, Lu, Yinghui, Wu, Junnan, Zhu, Xiaodong, Zhang, Mingchao, Yang, Fan, Xu, Xiaodong, Shi, Shaolin, Liu, Zhihong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534572/
https://ncbi.nlm.nih.gov/pubmed/31127093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1625-y
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