α-Synuclein–Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation

[Image: see text] α-Synuclein fibrils are considered a hallmark of Parkinson’s disease and other synucleinopathies. However, small oligomers that formed during the early stages of α-synuclein aggregation are thought to be the main toxic species causing disease. The formation of α-synuclein oligomers...

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Publié dans:Anal Chem
Auteurs principaux: Pérez-Pi, Irene, Evans, David A., Horrocks, Mathew H., Pham, Nhan T., Dolt, Karamjit S., Koszela, Joanna, Kunath, Tilo, Auer, Manfred
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534341/
https://ncbi.nlm.nih.gov/pubmed/30964656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b03842
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