Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review

BACKGROUND: The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment, while avoiding the risk of hepatotoxicity. OBJ...

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Publicado en:PLoS One
Main Authors: Toksvang, Linea Natalie, Schmidt, Magnus Strøh, Arup, Sofie, Larsen, Rikke Hebo, Frandsen, Thomas Leth, Schmiegelow, Kjeld, Rank, Cecilie Utke
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534292/
https://ncbi.nlm.nih.gov/pubmed/31125338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212157
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