Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors

BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the constitutive tyrosine kinase (TK) activity of the BCR-ABL1 fusion protein. Accordingly, TK inhibitors have drastically changed the disease prognosis. However, persistence of the transformed hematopoiesis even in...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Mancini, M., De Santis, S., Monaldi, C., Bavaro, L., Martelli, M., Castagnetti, F., Gugliotta, G., Rosti, G., Santucci, M. A., Martinelli, G., Cavo, M., Soverini, S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533706/
https://ncbi.nlm.nih.gov/pubmed/31122263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1197-9
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