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Regulation of drug metabolizing enzymes in the leukaemic bone marrow microenvironment

The bone marrow (BM) microenvironment contributes to drug resistance in acute myeloid leukaemia (AML) and multiple myeloma (MM). We have shown that the critical drug metabolizing enzymes cytochrome P450 (CYP) 3A4 and cytidine deaminase (CDA) are highly expressed by BM stroma, and play an important r...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Su, Meng, Chang, Yu‐Ting, Hernandez, Daniela, Jones, Richard J., Ghiaur, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533513/
https://ncbi.nlm.nih.gov/pubmed/30920135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14298
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