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BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly

Despite the great success of small molecule inhibitors in the treatment of patients with BRAF(V600E) mutated melanoma, the response to these drugs remains transient and patients eventually relapse within a few months, highlighting the need to develop novel combination therapies based on the understa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Frischknecht, Lukas, Britschgi, Christian, Galliker, Patricia, Christinat, Yann, Vichalkovski, Anton, Gstaiger, Matthias, Kovacs, Werner J., Krek, Wilhelm
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533289/
https://ncbi.nlm.nih.gov/pubmed/31123282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44112-7
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