PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier pr...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Shi, Kaixuan, Yin, Xia, Cai, Mei-Chun, Yan, Ying, Jia, Chenqiang, Ma, Pengfei, Zhang, Shengzhe, Zhang, Zhenfeng, Gu, Zhenyu, Zhang, Meiying, Di, Wen, Zhuang, Guanglei
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533083/
https://ncbi.nlm.nih.gov/pubmed/31050342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44306
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