Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy

PURPOSE: In the proper context, radiation therapy (RT) can promote anti-tumor immunity. It is unknown if elective nodal irradiation (ENI), a strategy that irradiates tumor-associated draining lymph nodes (DLN), impacts adaptive immune responses and combinatorial efficacy of RT with immune checkpoint...

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Published in:Clin Cancer Res
Main Authors: Marciscano, Ariel E., Ghasemzadeh, Ali, Nirschl, Thomas R., Theodros, Debebe, Kochel, Christina M., Francica, Brian J., Muroyama, Yuki, Anders, Robert A., Sharabi, Andrew B., Velarde, Esteban, Mao, Wendy, Chaudhary, Kunal R., Chaimowitz, Matthew G., Wong, John, Selby, Mark J., Thudium, Kent B., Korman, Alan J., Ulmert, David, Thorek, Daniel L.J., DeWeese, Theodore L., Drake, Charles G.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532976/
https://ncbi.nlm.nih.gov/pubmed/29898992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3427
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