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Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

BACKGROUND: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Vachon, Celine M., Scott, Christopher G., Tamimi, Rulla M., Thompson, Deborah J., Fasching, Peter A., Stone, Jennifer, Southey, Melissa C., Winham, Stacey, Lindström, Sara, Lilyquist, Jenna, Giles, Graham G., Milne, Roger L., MacInnis, Robert J., Baglietto, Laura, Li, Jingmei, Czene, Kamila, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Haeberle, Lothar, Eriksson, Mikael, Kraft, Peter, Luben, Robert, Wareham, Nick, Olson, Janet E., Norman, Aaron, Polley, Eric C., Maskarinec, Gertraud, Le Marchand, Loic, Haiman, Christopher A., Hopper, John L., Couch, Fergus J., Easton, Douglas F., Hall, Per, Chatterjee, Nilanjan, Garcia-Closas, Montse
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532188/
https://ncbi.nlm.nih.gov/pubmed/31118087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1138-8
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