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Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time

The HIV-1 Rev response element (RRE) is a cis-acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication. Most of our understanding of...

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Publicat a:J Virol
Autors principals: Sherpa, Chringma, Jackson, Patrick E. H., Gray, Laurie R., Anastos, Kathryn, Le Grice, Stuart F. J., Hammarskjold, Marie-Louise, Rekosh, David
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532081/
https://ncbi.nlm.nih.gov/pubmed/30867301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02102-18
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