Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice

Cardiolipin (CL) is a key mitochondrial phospholipid essential for mitochondrial energy production. CL is remodeled from monolysocardiolipin (MLCL) by the enzyme tafazzin (TAZ). Loss-of-function mutations in the gene which encodes TAZ results in a rare X-linked disorder called Barth Syndrome (BTHS)....

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Publicado no:Biochim Biophys Acta Mol Basis Dis
Main Authors: Cole, Laura K., Kim, Jin Hee, Amoscato, Andrew A., Tyurina, Yulia Y., Bayır, Hülya, Karimi, Benyamin, Siddiqui, Tabrez J., Kagan, Valerian E., Hatch, Grant M., Kauppinen, Tiina M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532065/
https://ncbi.nlm.nih.gov/pubmed/30055293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.07.022
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