A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART(®)

CD3 bispecific antibody constructs recruit cytolytic T cells to kill tumor cells, offering a potent approach to treat cancer. T cell activation is driven by the formation of a trimolecular complex (trimer) between drugs, T cells, and tumor cells, mimicking an immune synapse. A translational quantita...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Betts, Alison, Haddish-Berhane, Nahor, Shah, Dhaval K., van der Graaf, Piet H., Barletta, Frank, King, Lindsay, Clark, Tracey, Kamperschroer, Cris, Root, Adam, Hooper, Andrea, Chen, Xiaoying
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531394/
https://ncbi.nlm.nih.gov/pubmed/31119428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0332-z
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