Vaccine nanoparticles displaying recombinant Ebola virus glycoprotein for induction of potent antibody and polyfunctional T cell responses.

The recent outbreaks of Ebolavirus (EBOV) in West Africa underscore the urgent need to develop an effective EBOV vaccine. Here, we report the development of synthetic nanoparticles as a safe and highly immunogenic platform for vaccination against EBOV. We show that a large recombinant EBOV antigen (...

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Pubblicato in:Nanomedicine
Autori principali: Bazzill, Joseph D., Stronsky, Sabrina M., Kalinyak, Laura C., Ochyl, Lukasz J., Steffens, Jesse T., van Tongeren, Sean A., Cooper, Christopher L., Moon, James J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6531357/
https://ncbi.nlm.nih.gov/pubmed/30471480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2018.11.005
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