T-cell-dependent mechanisms promote Ebola VLP-induced antibody responses, but are dispensable for vaccine-mediated protection

Humoral responses are essential for the protective efficacy of most Ebola virus (EBOV) candidate vaccines; however, the in vivo development of protective anti-EBOV B-cell responses is poorly defined. Here, by using the virus-like particle (VLP) as a model antigen, we demonstrate that humoral respons...

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Detalhes bibliográficos
Publicado no:Emerg Microbes Infect
Main Authors: Cooper, Christopher L, Martins, Karen A, Stronsky, Sabrina M, Langan, David P, Steffens, Jesse, Van Tongeren, Sean, Bavari, Sina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520308/
https://ncbi.nlm.nih.gov/pubmed/28588288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2017.31
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