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NAD(+) biosensor reveals multiple sources for mitochondrial NAD(+)
Nicotinamide adenine dinucleotide (NAD(+)) is an essential substrate for sirtuins and ADP-ribose polymerases (PARPs), NAD(+)-consuming enzymes localized to the nucleus, cytosol, and mitochondria. Fluctuations in NAD(+) concentrations within these subcellular compartments are thought to regulate the...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6530784/ https://ncbi.nlm.nih.gov/pubmed/27313049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5168 |
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