Discovery of a glucocorticoid receptor (GR) activity signature using selective GR antagonism in ER-negative breast cancer

PURPOSE: Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)- negative breast cancer (BC) is associated with shortened relapse-free survival (RFS), how associated GR transcriptional activity contributes to aggressive BC behavior is not well understood. Using p...

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Pubblicato in:Clin Cancer Res
Autori principali: West, Diana C., Kocherginsky, Masha, Tonsing-Carter, Eva Y., Dolcen, D. Nesli, Hosfield, David J., Lastra, Ricardo R., Sinnwell, Jason P., Thompson, Kevin J., Bowie, Kathleen R., Harkless, Ryan V., Skor, Maxwell N., Pierce, Charles F., Styke, Sarah C., Kim, Caroline R., de Wet, Larischa, Greene, Geoffrey L., Boughey, Judy C., Goetz, Matthew P., Kalari, Krishna R., Wang, Liewei, Fleming, Gini F., Győrffy, Balázs, Conzen, Suzanne D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530562/
https://ncbi.nlm.nih.gov/pubmed/29636357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2793
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