Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer

Targetable molecular drivers for triple-negative breast cancer (TNBC) have been difficult to identify; therefore, standard treatment remains limited to conventional chemotherapy. Recently, new-generation small-molecule Hsp90 inhibitors (e.g., ganetespib and NVP-AUY922) have demonstrated improved saf...

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Bibliografiske detaljer
Udgivet i:Horm Cancer
Main Authors: Agyeman, Abena S., Jun, Wesley J., Proia, David A., Kim, Caroline R., Skor, Maxwell N., Kocherginsky, Masha, Conzen, Suzanne D.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2016
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789079/
https://ncbi.nlm.nih.gov/pubmed/26858237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-016-0251-8
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