Modifying Graft-versus-Host Disease in a Humanized Mouse Model by Targeting Macrophages or B-Cells

Humanized mouse models can well be modified to study specific aspects of Graft-versus-Host Disease (GvHD). This paper shows the results of both macrophage depletion and (early) B-cell depletion in a humanized mouse model using RAG2(−/−)γc(−/−) mice injected with HuPBMCs. Macrophage depletion showed...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Hogenes, Marieke C. H., van Dorp, Suzanne, van Kuik, Joyce, Monteiro, Filipa R. P., ter Hoeve, Natalie, Guedes, Liane, van Dijk, Marijke R., Martens, Anton C., de Weger, Roel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530157/
https://ncbi.nlm.nih.gov/pubmed/31205954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3538963
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