Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

BACKGROUND: Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), as the first metastatic site, is also the first site where BrC-induced suppression of immune effector subsets occurs. Since intricate knowle...

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Publicado en:J Immunother Cancer
Autores principales: van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., van de Ven, Rieneke, te Velde, Elisabeth A., Rutgers, Emiel J. Th., van den Tol, Petrousjka M., Stockmann, Hein B.A.C., de Gruijl, Tanja D.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530094/
https://ncbi.nlm.nih.gov/pubmed/31118093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0605-1
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